Morpholinoamidine → HCID 178517897、化合物

HRID 1507511

反応式

HRID 1507511 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]([C:16]([O:18]CC)=O)[C:11]([O:13]CC)=O.[N:21]1([C:27](=[NH:29])[NH2:28])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>C1(C)C=CC=CC=1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:11]([OH:13])=[N:28][C:27]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[N:29][C:16]=1[OH:18]

参加物

4

反応物 2

HCID 205053MorpholinoamidineHCID 3922432Propanedioic acid, 2-benzothiazolyl-, diethyl ester

生成物 1

HCID 178517897HCID 178517897、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture 1,3-diethyl 2-(1,3-benzothiazol-2-yl)propanedioate (3.00 g, 10.23 mmol, 1.00 equiv), and morpholine-4-carboximidamide (1.33 g, 10.30 mmol, 1.00 equiv) in Toluene (30 mL) was heated for 20 h at 120° C. under an inert atmosphere of nitrogen. After cooling down, the white solid was collected by filtration, washed with a mixture solution of Dichloromethane/Methanol and dried in an IR oven to afford the title compound. as a white solid. MS m/z [M+H]+ (ESI): 331.

後処理

  1. temperatureAfter cooling down
  2. filtrationthe white solid was collected by filtration
  3. washwashed with a mixture solution of Dichloromethane/Methanol
  4. customdried in an IR oven

出典と根拠

ORDレコード
ord-fc039b7d9efd457287a7034d818c6d6a
出典データセット
uspto-grants-2015_12
特許番号
US09221809B2

関連ノート

読み込み中…