Diethyl 2-(benzo[d]thiazol-2-yl)malonate → HCID 178517545、化合物

HRID 1507515

反応式

HRID 1507515 の反応式
[O:1]1[CH2:6][CH2:5][CH:4]([C:7](=[NH:9])[NH2:8])[CH2:3][CH2:2]1.[S:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]=[C:11]1[CH:19]([C:25](OCC)=[O:26])[C:20](OCC)=[O:21]>C1(C)C=CC=CC=1>[S:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]=[C:11]1[C:19]1[C:25]([OH:26])=[N:9][C:7]([CH:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[N:8][C:20]=1[OH:21]

参加物

4

反応物 2

HCID 3922432Diethyl 2-(benzo[d]thiazol-2-yl)malonateHCID 11355674HCID 11355674、化合物

生成物 1

HCID 178517545HCID 178517545、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of oxane-4-carboximidamide (160 mg, 1.25 mmol, 1.00 equiv), and 1,3-diethyl 2-(1,3-benzothiazol-2-yl)propanedioate (366 mg, 1.25 mmol, 1.00 equiv) in Toluene (3 mL) was heated for 3 h at 110° C. in an oil bath. After concentrated under reducing pressure, 460 mg (crude) of the title compound was obtained as a white solid, which was used directly for next step without further purification. MS m/z [M+H]+ (ESI): 330.

後処理

  1. concentrationAfter concentrated
  2. customwas obtained as a white solid, which
  3. customwas used directly for next step without further purification

出典と根拠

ORDレコード
ord-00036d3f50b740748774fd20f425435f
出典データセット
uspto-grants-2015_12
特許番号
US09221809B2

関連ノート

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