3-Fluoropyridine-4-carboxylic acid → N-(1-ethyl-3,3-dimethyl-2-oxoindolin-6-yl)-3-fluoroisonicotinamide

反応式

[F:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:25])([CH3:24])[C:17](=[O:23])[N:18]2[CH2:21][CH3:22])=[CH:14][CH:13]=1>>[CH2:21]([N:18]1[C:19]2[C:15](=[CH:14][CH:13]=[C:12]([NH:11][C:4](=[O:6])[C:3]3[CH:7]=[CH:8][N:9]=[CH:10][C:2]=3[F:1])[CH:20]=2)[C:16]([CH3:25])([CH3:24])[C:17]1=[O:23])[CH3:22]

参加物

反応物 2

HCID 3453613-Fluoropyridine-4-carboxylic acid

HCID 69068988HCID 69068988、化合物2 回

生成物 1

HCID 73425948N-(1-ethyl-3,3-dimethyl-2-oxoindolin-6-yl)-3-fluoroisonicotinamide

実験手順

Prepared in analogy to example 26 from 3-fluoroisonicotinic acid and 6-amino-1-ethyl-3,3-dimethylindolin-2-one (G. Georges et al., US2006/142247 A1). The title compound was obtained as light yellow solid.

出典と根拠

ORDレコード: ord-927aadaa1c3b4711a372aedc4594afc5
出典データセット: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09221816B2

反応ノート

読み込み中…