化工社化工社 化学情報印刷レポート · 研究参考用
Lithium Hydroxide → (4-Fluoroanilino)acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | ethyl N-(4-fluorophenyl)glycine | HCID 61998283 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (4-Fluoroanilino)acetic acid | HCID 1133296 | — |
反応手順
To a solution of 21.3 g (108 mmole) of ethyl N-(4-fluorophenyl)glycine in THF (100 mL) under nitrogen was added LiOH (5.44 g (130 mmol) monohydrate in 25 mL water. After 15 h the mixture was concentrated to half the volume and acidified to pH 3 with HCl. The precipitated solid was collected and washed with water (100 mL) to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09221805B2 |
| 出典データセット | uspto-grants-2015_12 |
| ORD ID | ord-29093dc73551402f8645b833fe1ed16d |
| 出典メモ | uspto-grants-2015_12 |