Potassium Carbonate → HCID 46916618、化合物

HRID 1507794ノート

反応式

HRID 1507794 の反応式
[NH2:1][C:2]1[N:3]=[C:4](S(C)(=O)=O)[C:5]2[N:10]=[C:9]([CH:11]3[CH2:13][CH2:12]3)[S:8][C:6]=2[N:7]=1.[C:18]([O-])([O-])=[O:19].[K+].[K+]>O1CCOCC1.CO>[NH2:1][C:2]1[N:3]=[C:4]([O:19][CH3:18])[C:5]2[N:10]=[C:9]([CH:11]3[CH2:13][CH2:12]3)[S:8][C:6]=2[N:7]=1

参加物

5

反応物 2

HCID 11430Potassium CarbonateHCID 66759187HCID 66759187、化合物

生成物 1

HCID 46916618HCID 46916618、化合物収率 90%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 5-amino-2-cyclopropyl-7-(methylsulfonyl)thiazolo[5,4-d]pyrimidine (54 mg, 0.2 mmol) and K2CO3 (69 mg, 0.5 mmol) in dioxane (10 ml) and methanol (5 ml) was stirred at room temperature overnight. The reaction mixture was evaporated in vacuo and purified by flash chromatography on silica, the mobile phase being a mixture of methanol and dichloromethane (in a ratio of 1/60), yielding the pure title compound (40 mg, 90%).

後処理

  1. customThe reaction mixture was evaporated in vacuo
  2. custompurified by flash chromatography on silica
  3. additiona mixture of methanol and dichloromethane (in a ratio of 1/60),

出典と根拠

ORDレコード
ord-9a513530143a4bfbad2b1a75a44d93d2
出典データセット
uspto-grants-2015_12
特許番号
US09221822B2

反応ノート

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