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HRID 15079作成日：2026年10月24日
Dimethylformamide → 4-[(5-Chloro-2-pyridinyl)methoxy]-1-(4-{2-[isopropyl(methyl)amino]ethoxy}-phenyl)-1H-pyridin-2-one
https://huagongshe.com/ja/reaction/15079
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | N-Methylisopropylamine | HCID 78485 | — |
| 反応物 | 1-[4-(2-bromoethoxy)phenyl]-4-[(5-chloro-2-pyridinyl)-methoxy]-1H-pyridin-2-one | HCID 68431096 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-[(5-Chloro-2-pyridinyl)methoxy]-1-(4-{2-[isopropyl(methyl)amino]ethoxy}-phenyl)-1H-pyridin-2-one | HCID 11640508 | 99% |
反応手順
A mixture of 1-[4-(2-bromoethoxy)phenyl]-4-[(5-chloro-2-pyridinyl)methoxy]-1H-pyridin-2-one (1.1 g, 2.6 mmols, Step (1) of Example 109), isopropyl(methyl)amine (0.811 mL, 7.8 mmols) and DMF (2.6 mL) was stirred at 60° C. for 2 days. Water was added to the reaction liquid and filtered. So obtained crude title compound was purified on silica gel column chromatography (KP-Sil FLASH 25+M, chloroform:methanol=1:0→5:1) to provide the title compound (1.1 g, 99%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07732456B2 |
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| 出典データセット | uspto-grants-2010_06 |
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| ORD ID | ord-931df4c3aadd420e897071d9b62616a7 |
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| 出典メモ | uspto-grants-2010_06 |
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