Ethyl 2-(5-nitropyridin-2-YL)acetate → [5-Amino-6-(4,4-dimethyl-cyclohex-1-enyl)-pyridin-2-yl]-acetic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]=1)[CH3:2].[CH3:16][C:17]1([CH3:26])[CH2:22][CH2:21][C:20](B(O)O)=[CH:19][CH2:18]1>>[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]([C:20]2[CH2:21][CH2:22][C:17]([CH3:26])([CH3:16])[CH2:18][CH:19]=2)[N:7]=1)[CH3:2]参加物
3
実験手順
This compound was prepared from (5-nitro-pyridin-2-yl)-acetic acid ethyl ester (as prepared in the previous step) according to the procedure for nitro reduction and bromination in Example 33, step (b), followed by Suzuki coupling to 4,4-dimethyl-1-cyclohexen-1-ylboronic acid according to the procedure in Example 1, step (e). Mass spectrum (APCI, m/z): Calcd. for C17H24N2O2, 289.2 (M+H). found 289.2.
後処理
- customas prepared in the previous step)