Ethyl 3-hydroxyfuro[2,3-c]pyridine-2-carboxylate → Furo[2,3-C]pyridin-3(2H)-one

HRID 1508198ノート

反応式

HRID 1508198 の反応式
C(OC([C:6]1[O:14][C:9]2=[CH:10][N:11]=[CH:12][CH:13]=[C:8]2[C:7]=1[OH:15])=O)C>Cl.O>[O:14]1[C:9]2=[CH:10][N:11]=[CH:12][CH:13]=[C:8]2[C:7](=[O:15])[CH2:6]1

参加物

4

反応物 1

HCID 54723934Ethyl 3-hydroxyfuro[2,3-c]pyridine-2-carboxylate

生成物 1

HCID 14199080Furo[2,3-C]pyridin-3(2H)-one

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒

実験手順

A suspension of 3-hydroxyfuro[2,3-c]pyridine-2-carboxylic acid ethyl ester (10 mmol) in 10 mL 25% HCl solution and 5 mL H2O was heated to reflux overnight. After cooling to RT, the reaction mixture was quenched with sat. aq. NaHCO3 solution and extracted with EtOAc. The combined organic layers were dried over MgSO4 and concentrated in vacuo to give the desired product as brown solid;

後処理

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customthe reaction mixture was quenched with sat. aq. NaHCO3 solution
  4. extractionextracted with EtOAc
  5. dry with materialThe combined organic layers were dried over MgSO4
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e8465752acde40e68505e484cd7c1730
出典データセット
uspto-grants-2015_12
特許番号
US09221832B2

反応ノート

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