Cyclopropylboronic acid → 3-Chloro-2-cyclopropylisonicotinic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH3:11])[C:6]=1[Cl:12])[CH3:2].[CH:14]1(B(O)O)C[CH2:15]1>>[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH:11]2[CH2:15][CH2:14]2)[C:6]=1[Cl:12])[CH3:2]参加物
3
実験手順
This compound was prepared using a method analogous to that of 3-chloro-2-methylisonicotinic acid ethyl ester (A.2.5.2), cyclopropylboronic acid replacing trimethylboroxine. Purification by CC (KP-SIL™ from Biotage) using Hept/EtOAc (9/1) gives the desired product as colorless oil;
後処理
- customThis compound was prepared
- customPurification by CC (KP-SIL™ from Biotage)
出典と根拠
- ORDレコード
- ord-5b296ee74e074b4b994864afebd20195
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09221832B2
反応ノート
読み込み中…