Sodium Methoxide → HCID 86069111、化合物

HRID 1508244ノート

反応式

HRID 1508244 の反応式
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[C:10](Br)=[CH:9][CH:8]=[N:7][C:6]=1[Cl:12])[CH3:2].[CH3:14][O-:15].[Na+]>CO.CCOC(C)=O>[CH2:1]([O:3][C:4](=[O:13])[C:5]1[C:10]([O:15][CH3:14])=[CH:9][CH:8]=[N:7][C:6]=1[Cl:12])[CH3:2]

参加物

5

反応物 2

HCID 10942334Sodium MethoxideHCID 84819634Ethyl 4-bromo-2-chloronicotinate

生成物 1

HCID 86069111HCID 86069111、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
40 °C

実験手順

To a solution of 4-bromo-2-chloronicotinic acid ethyl ester (5.06 mmol) in 15 mL MeOH was added 1.0 mL of a solution of NaOMe (30% in MeOH). The reaction mixture was stirred at 40° C. for 4 h, cooled to RT, diluted with EtOAc and then quenched with sat. aq. NH4Cl solution. The organic layers was dried over MgSO4 and concentrated in vacuo to give the desired compound as brown oil;

後処理

  1. temperaturecooled to RT
  2. customquenched with sat. aq. NH4Cl solution
  3. dry with materialThe organic layers was dried over MgSO4
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-f11930c306814e92a4e8cfe1c8246883
出典データセット
uspto-grants-2015_12
特許番号
US09221832B2

反応ノート

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