Diethyl Oxalate → Ethyl 2-oxo-3-phenylpropanoate

反応式

F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11].C(Br)C1C=CC=CC=1.[Mg].C(OCC)(=O)C(OCC)=O>>[C:3]1([CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1

参加物

反応物 4

HCID 7268Diethyl Oxalate

HCID 7498Benzyl Bromide

HCID 5462224Magnesium

HCID 18370709Ethyl (2-fluorophenyl)pyruvate

生成物 1

HCID 12292599Ethyl 2-oxo-3-phenylpropanoate収率 80%

実験手順

The title compound was prepared as described for B4 using benzyl bromide (1.250 g, 7.31 mmol), magnesium (0.195 g, 8.04 mmol) and diethyl oxalate (2.136 g, 14.62 mmol) in the form of colorless oil in 80% yield and used instantly in next step.

出典と根拠

ORDレコード: ord-52eb95a6d9b74cc5876a983ee0b66d2d
出典データセット: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09221860B2

反応ノート

読み込み中…