Diethyl Oxalate → Ethyl (3-methoxyphenyl)pyruvate

反応式

F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11].[CH3:16][O:17]C1C=C(C=CC=1)CBr.[Mg].C(OCC)(=O)C(OCC)=O>>[CH3:16][O:17][C:7]1[CH:2]=[C:3]([CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:4]=[CH:5][CH:6]=1

参加物

反応物 4

HCID 7268Diethyl Oxalate

HCID 40672073-Methoxybenzyl bromide

HCID 5462224Magnesium

HCID 18370709Ethyl (2-fluorophenyl)pyruvate

生成物 1

HCID 18370264Ethyl (3-methoxyphenyl)pyruvate収率 74%

実験手順

The title compound was prepared as described for B4 using 3-methoxybenzyl bromide (1.5 g, 7.46 mmol), magnesium (0.199 g, 8.21 mmol) and diethyl oxalate (2.18 g, 14.92 mmol). The product was isolated in the form of colorless oil in 74% yield and used instantly in next step.

後処理

customThe product was isolated in the form of colorless oil in 74% yield

出典と根拠

ORDレコード: ord-6e50e5f6f09c43fbac72a8d3d4cdacfb
出典データセット: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09221860B2

反応ノート

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