Diethyl Oxalate → Ethyl 3-(2-chlorophenyl)-2-oxopropanoate

HRID 1508433ノート

反応式

HRID 1508433 の反応式
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11].[Cl:16]C1C=CC=CC=1CCl.[Mg].C(OCC)(=O)C(OCC)=O>>[Cl:16][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11]

参加物

5

反応物 4

HCID 7268Diethyl OxalateHCID 119062-Chlorobenzyl chlorideHCID 5462224MagnesiumHCID 18370709Ethyl (2-fluorophenyl)pyruvate

生成物 1

HCID 18370191Ethyl 3-(2-chlorophenyl)-2-oxopropanoate収率 74%

実験手順

The title compound was prepared as described for B4 using 2-chlorobenzyl chloride (1.250 g, 7.76 mmol), magnesium (0.208 g, 8.54 mmol), diethyl oxalate (2.269 g, 15.53 mmol). The product was isolated in the form of colorless oil in 74% yield and use instantly in next step.

後処理

  1. customThe product was isolated in the form of colorless oil in 74% yield and use instantly in next step

出典と根拠

ORDレコード
ord-b31077831152426bb20b4d487dcc08d2
出典データセット
uspto-grants-2015_12
特許番号
US09221860B2

反応ノート

読み込み中…