Diethyl Oxalate → Ethyl (2-bromophenyl)pyruvate

HRID 1508448ノート

反応式

HRID 1508448 の反応式
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11].[Br:16]C1C=C(C=CC=1)CBr.[Mg].C(OCC)(=O)C(OCC)=O>>[Br:16][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11]

参加物

5

反応物 4

HCID 7268Diethyl OxalateHCID 699793-Bromobenzyl bromideHCID 5462224MagnesiumHCID 18370709Ethyl (2-fluorophenyl)pyruvate

生成物 1

HCID 18370522Ethyl (2-bromophenyl)pyruvate収率 80%

実験手順

The title compound was prepared as described for B4 using 3-bromobenzyl bromide (1.250 g, 5.00 mmol), magnesium (0.134 g, 5.50 mmol) and diethyl oxalate (1.462 g, 10.00 mmol). The product was isolated in the form of colorless oil in 80% yield and use instantly in next step.

後処理

  1. customThe product was isolated in the form of colorless oil in 80% yield and use instantly in next step

出典と根拠

ORDレコード
ord-5a9e0228d1a441ecabf88c1f70b4576f
出典データセット
uspto-grants-2015_12
特許番号
US09221860B2

反応ノート

読み込み中…