Trimethylsilyldiazomethane → (5-(Methoxycarbonyl)furan-2-YL)boronic acid
反応式
[OH:1][B:2]([OH:11])[C:3]1[O:7][C:6]([C:8]([OH:10])=[O:9])=[CH:5][CH:4]=1.[CH3:12][Si](C=[N+]=[N-])(C)C>C(Cl)Cl.CO>[CH3:12][O:9][C:8]([C:6]1[O:7][C:3]([B:2]([OH:1])[OH:11])=[CH:4][CH:5]=1)=[O:10]参加物
5
実験手順
5-(Dihydroxyboryl)-2-furoic acid (200 mg, 1.283 mmol) was dissolved in CH2Cl2 (5 mL) and MeOH (0.556 mL). Trimethylsilyldiazomethane (1.283 mL, 2.57 mmol) was added dropwise. After 45 min, the reaction was quenched with AcOH dropwise until the yellow color disappeared. The reaction was concentrated in vacuo to give [5-(methoxycarbonyl)-2-furyl]boronic acid. 1H NMR (500 MHz, CD3OD): δ 7.20 (d, J=3.5 Hz, 1H); 7.05 (d, J=3.6 Hz, 1H); 3.87 (s, 3H).
後処理
- customthe reaction was quenched with AcOH dropwise until the yellow color
- concentrationThe reaction was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-1b41a39b4e1449f395f6ec3450c06de5
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09221834B2
反応ノート
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