Sodium Bicarbonate → 5-Ethyl-4-hydroxy-6-methyl-2(1H)-pyridinone

HRID 1508687ノート

反応式

HRID 1508687 の反応式
[CH2:1]([C:3]1[C:4]([OH:16])=[C:5](C(OCC)=O)[C:6](=[O:10])[NH:7][C:8]=1[CH3:9])[CH3:2].C([O-])(O)=O.[Na+]>Cl>[CH2:1]([C:3]1[C:4]([OH:16])=[CH:5][C:6](=[O:10])[NH:7][C:8]=1[CH3:9])[CH3:2]

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 54706937Ethyl 5-ethyl-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate

生成物 1

HCID 547073435-Ethyl-4-hydroxy-6-methyl-2(1H)-pyridinone収率 54%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A 50-mL round bottom flask was charged with ethyl 5-ethyl-4-hydroxy-6-methyl-2-oxo-1H-pyridine-3-carboxylate (117 mg, 0.52 mmol) and 1N HCl (10 ml). The mixture was stirred under reflux overnight. After cooling to room temperature, the mixture was neutralized by addition of aqueous NaHCO3 to pH=7. The precipitate was collected by filtration and washed with water. After dried, 5-ethyl-4-hydroxy-6-methyl-1H-pyridin-2-one was obtained (43 mg, 54% yield).

後処理

  1. temperatureunder reflux overnight
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customAfter dried

出典と根拠

ORDレコード
ord-09e5c92ff6ed4a59b3e7a648326768ca
出典データセット
uspto-grants-2015_12
特許番号
US09221843B2

反応ノート

読み込み中…