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4-(Trifluoromethyl)phenyl isothiocyanate → Raf265
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Trifluoromethyl)phenyl isothiocyanate | HCID 137134 | — |
| 反応物 | Thiourea | HCID 2723790 | — |
| 反応物 | 1,2-Benzenediamine,n1-methyl-4-[[2-[5-(trifluoromethyl)-1h-imidazol-2-yl]-4-pyridinyl]oxy]- | HCID 57531890 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | Phosphorus oxychloride | HCID 24813 | — |
| 生成物 | Raf265 | HCID 11656518 | — |
反応手順
4-Trifluoromethylphenyl isothiocyanate (200 mg, 1 mmol) was added to a mixture of 4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N1-methylbenzene-1,2-diamine (350 mg, 1 mmol) in 3 mL of acetonitrile. After stirring for 20 min at ambient temperature, HPLC analysis showed complete conversion. A mixture of thiourea (553 mg, 1 mmol) in POCl3 (3 mL) was stirred at ambient temperature. After 4 h, the mixture was heated to approximately 50° C. After heating for 2 h, HPLC analysis indicated completion of reaction:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732465B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-d874d789a81547719f2e9f1c4c305bff |
| 出典メモ | uspto-grants-2010_06 |