関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Succinic anhydride | HCID 7922 | — |
| 反応物 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 反応物 | Salvinorin B | HCID 11440685 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Salvinorin A | HCID 128563 | — |
反応手順
To Salvinorin B (190 mg, 0.487 mmol) and succinic anhydride (112 mg, 2.5 eq) suspended in dichloromethane (5 ml) at 0° C. was added DBU (218 pl, 3 eq) dropwise. The mixture was stirred at 0° C. for 15 mins, washed with 3% citric acid (5 ml), saturated NaHCO3 solution (5 ml) and brine (5 ml). The mixture was dried over sodium sulfate, filtered and evaporated to dryness. The crude residue was purified by column chromatography (silica gel: CH2Cl2 to 5% MeOH in CH2Cl2) to give salvinorin hemisuccinate (130 mg, 54%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09222949B2 |
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| 出典データセット | uspto-grants-2015_12 |
|---|
| ORD ID | ord-82dd4338f69d45bfb15f0f0965eaa3cd |
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| 出典メモ | uspto-grants-2015_12 |
|---|
