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4-Methylmorpholine → 5-chloro-thiophene-2-carboxylic acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 反応物 | 3-Chloro-4-[(pyrrolidin-1-yl)carbonyl]aniline | HCID 16777853 | — |
| 反応物 | 2-[(5-Chloro-thiophene-2-carbonyl)-amino]-propionic acid | HCID 43239338 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-chloro-thiophene-2-carboxylic acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide | HCID 11640731 | — |
反応手順
Prepared analogously to Example 1a from 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid and 3-chloro-4-(pyrrolidin-1-yl-carbonyl)-aniline with TBTU and NMM in DMF.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732466B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-dcdbdac0a56e40299e8b1ada792d2b70 |
| 出典メモ | uspto-grants-2010_06 |