6-Hydroxy-1-naphthoic acid → HCID 24822772、化合物

反応式

[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([C:12]([OH:14])=[O:13])=[CH:7][CH:6]=[CH:5]2.Cl[C:16]1[C:25]2[C:20](=[CH:21][C:22]([O:26][CH3:27])=[CH:23][CH:24]=2)[N:19]=[CH:18][CH:17]=1>>[CH3:27][O:26][C:22]1[CH:21]=[C:20]2[C:25]([C:16]([O:1][C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[C:8]([C:12]([OH:14])=[O:13])=[CH:7][CH:6]=[CH:5]4)=[CH:17][CH:18]=[N:19]2)=[CH:24][CH:23]=1

参加物

反応物 2

HCID 54638006-Hydroxy-1-naphthoic acid

HCID 106078294-Chloro-7-methoxyquinoline

生成物 1

HCID 24822772HCID 24822772、化合物収率 66%

実験手順

The title compound (1.73 g, 66% yield) was prepared as a brown solid from 6-hydroxy-1-naphthoic acid (1.43 g, 7.6 mmol) and 4-chloro-7-methoxyquinoline (1.77 g, 9.14 mmol) by an analogous procedure to that described in example 1. LC-MS (m/z) 346 (M+1).

出典と根拠

ORDレコード: ord-657df3e00cf544518415e598989a52ea
出典データセット: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08211901B2

反応ノート

読み込み中…