Carbon Tetrachloride → 1-(Chloromethyl)-3-(1-cyclopropylethoxy)benzene

反応式

[CH:1]1([CH:4]([O:6][C:7]2[CH:8]=[C:9]([CH2:13]O)[CH:10]=[CH:11][CH:12]=2)[CH3:5])[CH2:3][CH2:2]1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(Cl)(Cl)(Cl)[Cl:35]>>[Cl:35][CH2:13][C:9]1[CH:10]=[CH:11][CH:12]=[C:7]([O:6][CH:4]([CH:1]2[CH2:3][CH2:2]2)[CH3:5])[CH:8]=1

参加物

反応物 3

HCID 5943Carbon Tetrachloride

HCID 11776Triphenylphosphine

HCID 66789951HCID 66789951、化合物

生成物 1

HCID 667899501-(Chloromethyl)-3-(1-cyclopropylethoxy)benzene

反応条件

温度: 78 °C

実験手順

[3-(1-cyclopropylethoxy)phenyl]methanol (0.418 g, 2.17 mmol) in carbon tetrachloride (8.70 ml) was added triphenylphosphine resin (1.14 g, 4.35 mmol). The reaction was refluxed overnight with minimal stirring at 78° C. The next day the mixture was filtered through a fritted funnel and washed with dichloromethane. The filtrate was concentrated and no purification was necessary.