Chloroiodomethane → Methyl 3-cyclopropoxybenzoate
反応式
[CH:1]([O:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])=[CH2:2].I[CH2:15]Cl.C([Zn]CC)C>ClC(Cl)C>[CH:1]1([O:3][C:4]2[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=2)[C:7]([O:9][CH3:10])=[O:8])[CH2:15][CH2:2]1参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a solution of methyl 3-(vinyloxy)benzoate (0.83 g, 3.99 mmol) in dichloroethane (20 mL) was added iodochloromethane (1.09 mL, 14.9 mmol). The solution was cooled to 0° C. and diethyl zinc (1.0 M in hexanes, 7.48 mL, 7.48 mmol) was added. The cooling bath was removed and the reaction was stirred at rt for 30 min. The reaction mixture was quenched with 1N HCl, extracted with methylene chloride (three times), dried with MgSO4 and concentrate under vacuum to afford the desired product.
後処理
- customThe cooling bath was removed
- customThe reaction mixture was quenched with 1N HCl
- extractionextracted with methylene chloride (three times)
- dry with materialdried with MgSO4
- concentrationconcentrate under vacuum
出典と根拠
- ORDレコード
- ord-9da18a6a5ae843529c2bb78ba53a0227
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08211904B2
反応ノート
読み込み中…