Benzyl 2-methyl-4-oxopiperidine-1-carboxylate → Benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate

HRID 1510147ノート

反応式

HRID 1510147 の反応式
[CH3:1][CH:2]1[CH2:7][C:6](=[O:8])[CH2:5][CH2:4][N:3]1[C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10]>CO>[CH3:1][C@H:2]1[CH2:7][C:6](=[O:8])[CH2:5][CH2:4][N:3]1[C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10]

参加物

3

反応物 1

HCID 46941997Benzyl 2-methyl-4-oxopiperidine-1-carboxylate

生成物 1

HCID 57475593Benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The crude Racemic benzyl 2-methyl-4-oxopiperidine-1-carboxylate was dissolved in MeOH and chromatographed on a 10 cm Chiralpak AD column eluting with 100% MeOH in 2.5 g injections to give the two separated enantiomers. The desired enantiomer eluted first, 95% ee.

後処理

  1. customchromatographed on a 10 cm Chiralpak AD column
  2. washeluting with 100% MeOH in 2.5 g injections
  3. customto give the two separated enantiomers
  4. washThe desired enantiomer eluted first

出典と根拠

ORDレコード
ord-b930b4c6992d4d1d90b8a4e5ea707c32
出典データセット
uspto-grants-2012_07
特許番号
US08211904B2

反応ノート

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