Stannous Chloride → HCID 20117328、化合物
反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[N:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[N:8][CH:9]=1)([O-])=O.Cl[Sn]Cl>Cl>[N:17]1[CH:18]=[CH:19][CH:20]=[N:21][C:16]=1[N:13]1[CH2:12][CH2:11][N:10]([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH2:15][CH2:14]1参加物
4
実験手順
To a solution of 2-[4-(5-nitro-pyridin-2-yl)-piperazin-1-yl]-pyrimidine (600 mg, 2.1 mmol) from above in 2N hydrochloric acid (7.50 mL) was added SnCl2 (1.60 g, 8.4 mmol). The mixture was stirred at room temperature for 2 hr. The mixture was evaporated to dryness and basified with 1N NaOH. The crude solid was triturated in methanol to afford 6-(4-pyrimidin-2-yl-piperazin-1-yl)-pyridin-3-ylamine as a yellow solid. The NMR spectrum obtained on the sample is compatible with its structure. LCMS calcd for C13H16N6 (m/e) 256, obsd 257 (M+H).