Toluene → Pyrido[2,3-b]pyrazin-2(1H)-one
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH2:7])[C:2]=1[NH2:8].C1(C)C=CC=CC=1.[O:16]=[CH:17][C:18](OCC)=O.C(OCC)C>O1CCOCC1>[NH:7]1[C:17](=[O:16])[CH:18]=[N:8][C:2]2[N:1]=[CH:6][CH:5]=[CH:4][C:3]1=2参加物
6
実験手順
To a suspension of 3.8 g of pyridine-2,3-diamine in 100 mL of dioxane, 7.1 g of a 45 to 50% toluene solution of ethyl oxoacetate was added, and the mixture was stirred at room temperature for 1 hour, and then heated under reflux while stirring for 1 hour. The reaction mixture was cooled with ice bath, and diethyl ether was added thereto. The solid was filtered off to obtain 3.9 g of pyrido(2,3-b)pyrazin-2(1H)-one as a light brown solid.
後処理
- additionwas added
- temperatureheated
- temperatureunder reflux
- stirringwhile stirring for 1 hour
- temperatureThe reaction mixture was cooled with ice bath
- filtrationThe solid was filtered off
出典と根拠
- ORDレコード
- ord-5e4ff97e02ba4dcd93d19792df7189bc
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08211908B2
反応ノート
読み込み中…