化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 3-Isobutyl-tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 4-oxobutanoate | HCID 82395 | — |
| 反応物 | 2-Amino-4-methylpentanamide hydrochloride | HCID 12866300 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Isobutyl-tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione | HCID 19770792 | 74.7% |
反応手順
To a solution of DL-leucinamide hydrochloride (1.5 g, 9 mmol) in water (40 ml), adjusted to pH 9.5 with 10% sodium hydroxide, ethyl-4-oxobutanoate (1 g, 7.5 mmol) was added. The mixture was placed in a microwave oven and refluxed for 1 hour. Water was then evaporated under vacuum and the residue was chromatographated over silica gel (CH2Cl2/MeOH/NH4OH 98/2/0.1) to afford 1.1 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732473B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-d2df26a4f3b342069645ec4d14109d98 |
| 出典メモ | uspto-grants-2010_06 |