Formamide → 4-chloroisoindole-1,3-dione
反応式
[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([O:7][C:8](=O)[C:3]=12)=[O:6].C([NH2:15])=O>O>[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:3]=1[C:8](=[O:7])[NH:15][C:5]2=[O:6]参加物
4
反応条件
- 温度
- 125 °C
実験手順
A mixture of 3-chlorophthalic acid anhydride (9 g, 49.2 mmol) and formamide (100 mL) was heated to 125° C. and stirred for 3 h. Water (300 mL) was then added and the mixture was cooled to room temperature. The mixture was filtered and the resulting white solid was washed with water and dried to give 4-chloro-1H-isoindole-1,3(2H)-dione (7.7 g, 86% yield).
後処理
- temperaturethe mixture was cooled to room temperature
- filtrationThe mixture was filtered
- washthe resulting white solid was washed with water
- customdried
出典と根拠
- ORDレコード
- ord-1f72a5a000e641f6b622ab01e30fdc42
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08216999B2
反応ノート
読み込み中…