1-Bromo 4-fluoronaphthalene → 4-(4-Bromonaphthalen-1-yloxy)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

HRID 1511636ノート

反応式

HRID 1511636 の反応式
[S:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH:9]([OH:10])[C:4]=2[CH:3]=[CH:2]1.[Br:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15](F)=[CH:14][CH:13]=1>>[Br:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([O:10][CH:9]2[CH2:8][NH:7][CH2:6][C:5]3[S:1][CH:2]=[CH:3][C:4]2=3)=[CH:14][CH:13]=1

参加物

3

反応物 2

HCID 676471-Bromo 4-fluoronaphthaleneHCID 123370234,5,6,7-Tetrahydrothieno[2,3-c]pyridin-4-ol

生成物 1

HCID 684105174-(4-Bromonaphthalen-1-yloxy)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

実験手順

The same method as in Example 1 was conducted using 4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 5) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 1-bromo-4-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

後処理

  1. customto give the objective compound

出典と根拠

ORDレコード
ord-7656617c364645b483b86865d5f2dae3
出典データセット
uspto-grants-2012_07
特許番号
US08217031B2

反応ノート

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