Benzene, 1,2-dichloro-3-fluoro- → 4-(2,3-Dichlorophenyloxy)-2-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride
反応式
[CH3:1][C:2]1[O:12][C:5]2[CH2:6][NH:7][CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.[Cl:13][C:14]1[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][C:15]=1F>>[ClH:13].[Cl:13][C:14]1[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][C:15]=1[O:11][CH:10]1[CH2:9][CH2:8][NH:7][CH2:6][C:5]2[O:12][C:2]([CH3:1])=[CH:3][C:4]1=2参加物
3
実験手順
The same method as in Example 3 was conducted using 2-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 44) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.
後処理
- customto give the objective compound
出典と根拠
- ORDレコード
- ord-4f2f312eaaea47a2b9b341228ac52c1e
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08217031B2
反応ノート
読み込み中…