4-Methyloxane-4-carbaldehyde → HCID 178506127、化合物
反応式
[Br:1][C:2]12[CH2:9][CH2:8][C:5]([CH:10]=[CH:11][C:12](Cl)=O)([CH2:6][CH2:7]1)[CH2:4][CH2:3]2.COC(C12CCC(Br)(CC1)CC2)=O.CC1(C=O)CCOCC1.[N+:37]([C:40]1[CH:41]=[C:42]([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][C:48]=2[C:53]([F:56])([F:55])[F:54])[CH:43]=[CH:44][C:45]=1[NH2:46])([O-])=O>>[Br:1][C:2]12[CH2:9][CH2:8][C:5](/[CH:10]=[CH:11]/[C:12]3[NH:46][C:45]4[CH:44]=[CH:43][C:42]([C:47]5[CH:52]=[CH:51][CH:50]=[CH:49][C:48]=5[C:53]([F:54])([F:55])[F:56])=[CH:41][C:40]=4[N:37]=3)([CH2:6][CH2:7]1)[CH2:4][CH2:3]2参加物
5
実験手順
(E)-2-[2-(4-Bromo-bicyclo[2.2.2]oct-1-yl)-vinyl]-5-(2-trifluoromethyl-phenyl)-1H-benzoimidazole was prepared from 3-(4-bromo-bicyclo[2.2.2]oct-1-yl)-acryloyl chloride (prepared from 4-bromo-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester utilizing a procedure analogues to the preparation of 4-methyl-tetrahydro-pyran-4-carbaldehyde in Example 9) and 3-nitro-2′-trifluoromethyl-biphenyl-4-ylamine (prepared as described in Example 3, STEP A) according to the procedure as described in Example 9, STEPS A-C.