Hydrochloric Acid → 6-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione hydrochloride

HRID 1513355ノート

反応式

HRID 1513355 の反応式
[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:34])[NH:10][C:11](=[O:33])[N:12]([CH2:14][CH2:15][CH2:16][N:17]3[CH2:22][C@H:21]4[C@:19]([C:23]5[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=5)([CH2:20]4)[CH2:18]3)[N:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:35]>C(OCC)C>[ClH:35].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:34])[NH:10][C:11](=[O:33])[N:12]([CH2:14][CH2:15][CH2:16][N:17]3[CH2:22][C@H:21]4[C@:19]([C:23]5[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=5)([CH2:20]4)[CH2:18]3)[N:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 594960896-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione

生成物 1

HCID 686536986-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione hydrochloride

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

6-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione (19.7 mg 0.041 mmol, prepared following an analoguos procedure to that described for Ex9) was diluted in diethyl ether (1 ml) and hydrochloric acid 1M in Et2O (0.045 ml, 0.045 mmol) under nitrogen atmosphere. Solvent was removed and the residue triturated in Et2O (2×1 mL), obtaining 21.8 mg of title compound as a white solid.

後処理

  1. customSolvent was removed
  2. customthe residue triturated in Et2O (2×1 mL)

出典と根拠

ORDレコード
ord-c9b64724bf9a47e9916d58761274a029
出典データセット
uspto-grants-2012_07
特許番号
US08217168B2

反応ノート

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