Potassium Carbonate → HCID 57860590、化合物

反応式

[CH2:1]([C:3]1[N:8]([CH2:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:7](=[O:18])[C:6]2[C:19]([O:28][CH:29]([CH3:31])[CH3:30])=[C:20]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[N:21]([CH3:22])[C:5]=2[CH:4]=1)[CH3:2].C(=O)([O-])[O-].[K+].[K+].S(OC(C)C)(OC(C)C)(=O)=O>>[CH2:1]([C:3]1[N:8]([CH2:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:7](=[O:18])[C:6]2[C:19]([O:28][CH:29]([CH3:30])[CH3:31])=[C:20]([C:23]([OH:25])=[O:24])[N:21]([CH3:22])[C:5]=2[CH:4]=1)[CH3:2].[CH2:1]([C:3]1[N:8]([CH2:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:7](=[O:18])[C:6]2[C:19]([O:28][CH:29]([CH3:31])[CH3:30])=[C:20]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[N:21]([CH3:22])[C:5]=2[CH:4]=1)[CH3:2]

参加物

反応物 3

HCID 11430Potassium Carbonate

HCID 18096Diisopropyl sulfate

HCID 66893015HCID 66893015、化合物

生成物 2

HCID 57860590HCID 57860590、化合物収率 97%

HCID 66893015HCID 66893015、化合物

実験手順

In the same manner as in Reference Example 56, ethyl 6-ethyl-1-methyl-3-(1-methylethoxy)-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (291 mg, 46%) was obtained as a pale-purple powder from the compound of Reference Example 40 (574 mg, 1.50 mmol), potassium carbonate (1.04 g, 7.5 mmol) and diisopropyl sulfate (1.37 g, 7.5 mmol). The title compound (242 mg, 97%) was obtained as a colorless powder from the thus-obtained ethyl 6-ethyl-1-methyl-3-(1-methylethoxy)-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (267 mg, 0.63 mmol) by a method similar to that in Reference Example 59.