Hydrazine → 1-(6-(3-Methylisothiazol-5-yl)pyridazin-3-yl)hydrazine
反応式
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[S:12][N:11]=[C:10]([CH3:13])[CH:9]=2)=[CH:6][CH:7]=1.[NH2:14][NH2:15]>C(O)(CC)C.O>[CH3:13][C:10]1[CH:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([NH:14][NH2:15])=[CH:7][CH:6]=2)[S:12][N:11]=1参加物
5
反応条件
- 温度
- 130 °C
実験手順
A mixture of 3-chloro-6-(3-methylisothiazol-5-yl)pyridazine (0.85 g, 4.0 mmol) and anhydrous hydrazine (3.8 ml, 120 mmol) in 30 mL of sec-BuOH was heated at 130° C. for 3 hours. The mixture was cooled to 23° C. and diluted with 5 mL of water. The solid was collected by filtration and was washed by 2 mL of water to produce a yellow solid. MS (ESI pos. ion) m/z: 208 (MH+). Calc'd exact mass for C8H6ClN3S: 207.
後処理
- temperatureThe mixture was cooled to 23° C.
- filtrationThe solid was collected by filtration
- washwas washed by 2 mL of water
- customto produce a yellow solid
出典と根拠
- ORDレコード
- ord-df9d5dc68b484dc280837c8b54b01c07
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08217177B2
反応ノート
読み込み中…