Methyl 2-[(2-aminoethyl)oxy]-3-(methyloxy)benzoate → 9-methoxy-3,4-dihydro-1,4-benzoxazepin-5(2H)-one
反応式
[NH2:1][CH2:2][CH2:3][O:4][C:5]1[C:14]([O:15][CH3:16])=[CH:13][CH:12]=[CH:11][C:6]=1[C:7](OC)=[O:8]>C1(C)C=CC=CC=1>[CH3:16][O:15][C:14]1[C:5]2[O:4][CH2:3][CH2:2][NH:1][C:7](=[O:8])[C:6]=2[CH:11]=[CH:12][CH:13]=1参加物
3
反応条件
- 温度
- 110 °C
実験手順
A solution of methyl 2-[(2-aminoethyl)oxy]-3-(methyloxy)benzoate (Preparation 56) (11.9 g, 52.8 mmol) in toluene (200 ml) was stirred and heated at 110° C. for 1 hour then cooled and evaporated to give the title compound (10.3 g) as a sandy coloured solid. MS (ES): C10H11NO3 requires 193; found 194 [M+H]+.
後処理
- temperaturethen cooled
- customevaporated
出典と根拠
- ORDレコード
- ord-a9a7a0993cb54828b308306e1bbf2bb5
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08222245B2
反応ノート
読み込み中…