Hydrochloric Acid → 9-(5-{5-Chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride

HRID 1514246ノート

反応式

HRID 1514246 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[O:16][N:15]=[C:14]([C:17]3[C:27]4[O:26][CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][C:21]=4[CH:20]=[CH:19][CH:18]=3)[N:13]=2)[CH:5]=[N:6][C:7]=1[O:8][CH:9]([CH3:11])[CH3:10].Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[O:16][N:15]=[C:14]([C:17]3[C:27]4[O:26][CH2:25][CH2:24][NH:23][CH2:22][C:21]=4[CH:20]=[CH:19][CH:18]=3)[N:13]=2)[CH:5]=[N:6][C:7]=1[O:8][CH:9]([CH3:11])[CH3:10]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 594034701,1-Dimethylethyl 9-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

生成物 1

HCID 684690769-(5-{5-Chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride収率 206%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

反応条件

温度
60 °C

実験手順

A mixture of 1,1-dimethylethyl 9-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (Preparation 89) (190 mg, 0.390 mmol), 4M hydrogen chloride in dioxane (1 ml, 4.00 mmol) and 1,4-dioxane (10 ml) was stirred at 60° C. overnight. The reaction mixture was cooled and a white precipitate formed. The solid was filtered off to give the product as a white solid (170 mg). MS (ES) C19H1935ClN4O3 requires 386 Found 387 [M+H]+.

後処理

  1. temperatureThe reaction mixture was cooled
  2. customa white precipitate formed
  3. filtrationThe solid was filtered off

出典と根拠

ORDレコード
ord-2adad847073943b4b2a2e895c5291b3d
出典データセット
uspto-grants-2012_07
特許番号
US08222245B2

反応ノート

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