Methanol → 2-Methanesulfonyl-5-methyl-4-pyridin-3-yl-pyrimidine
反応式
[CH3:1][C:2]1[C:3]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[N:4][C:5](SC)=[N:6][CH:7]=1.O[O:17][S:18]([O-:20])=O.[K+].[CH3:22]O>>[CH3:22][S:18]([C:5]1[N:4]=[C:3]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[C:2]([CH3:1])=[CH:7][N:6]=1)(=[O:20])=[O:17]参加物
4
実験手順
A solution of 5-methyl-2-methylsulfanyl-4-pyridin-3-yl-pyrimidine (1.28 g, 5.90 mmol) in MeOH (45 ml) was cooled at 0° C. and then an aqueous solution of oxone (11 g, 17.95 mmol in 45 ml of water) was added dropwise. After 15 minutes, ice bath was removed and the stirring continue for 3 hours. The mixture was neutralized with solid NaHCO3 and the product was extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 1.3 g of the title compound as a white powder (88% yield).