Sodium Bicarbonate → HCID 178517452、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][N:11]=[C:10](SC)[N:9]=1.C([O-])(O)=[O:17].[Na+]>Cl.O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][NH:11][C:10](=[O:17])[N:9]=1参加物
5
実験手順
A solution of 4-(2-fluoro-phenyl)-2-methylsulfanyl-pyrimidine (943 mg, 4.28 mmol) in 37% HCl (18 ml) was heated at 100° C. for 21 hours. The mixture was diluted with water then basified with solid NaHCO3. The suspension was extracted with DCM; the organic layer was dried (Na2SO4), filtered and evaporated to give the title compound that was used without further purification in the next step (725 mg, 89% yield)
後処理
- extractionThe suspension was extracted with DCM
- dry with materialthe organic layer was dried (Na2SO4)
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-54b778663d2c4b1d88bb02cc830d66f5
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08222266B2
反応ノート
読み込み中…