1,4-Dioxane → HCID 178432715、化合物

反応式

[CH3:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][N:11]=[C:10](S(C)(=O)=O)[N:9]=2)=[C:5]([CH3:7])[N:6]=1.[O:18]1CCOCC1>>[CH3:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][NH:11][C:10](=[O:18])[N:9]=2)=[C:5]([CH3:7])[N:6]=1

参加物

反応物 2

HCID 312751,4-Dioxane

HCID 58742216HCID 58742216、化合物

生成物 1

HCID 178432715HCID 178432715、化合物収率 75%

実験手順

4-(2,4-dimethyl-thiazol-5-yl)-2-methanesulfonyl-pyrimidine (288 mg, 1.07 mmol) was dissolved in dioxane (13 ml) and then 2N NaOHaq (6 ml, 12 mmol) was added. After stirring at room temperature for 1 hour, the solution was acidified with 37% HClaq. The mixture was evaporated and the residue was purified by flash chromatography with DCM-MeOH (9-1) to give 166 mg of the title compound. (75% yield).

後処理

addition2N NaOHaq (6 ml, 12 mmol) was added
customThe mixture was evaporated
customthe residue was purified by flash chromatography with DCM-MeOH (9-1)

出典と根拠

ORDレコード: ord-f04966f02b6148c6b164dce2ca69c469
出典データセット: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08222266B2

反応ノート

読み込み中…

参加物