Hydrochloric Acid → HCID 66672505、化合物

反応式

[C:1]([C:5]1[N:9]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([CH3:18])=[C:7]([C:19]([O:21]CC)=[O:20])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[K+].Cl>C(O)C>[C:1]([C:5]1[N:9]([CH2:10][CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:8]([CH3:18])=[C:7]([C:19]([OH:21])=[O:20])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

反応条件

温度: 100 °C

実験手順

A 300 mg portion of ethyl 5-tert-butyl-2-methyl-1-(2-phenylethyl)-1H-pyrrole-3-carboxylate was suspended in 9 ml of ethanol, and 1.8 ml of a 8 M potassium hydroxide aqueous solution was added, followed by stirring overnight at 100° C. The reaction liquid was cooled to room temperature, adjusted to pH 1 by adding 6 M hydrochloric acid and 1 M hydrochloric acid under ice-cooling, and then stirred at the same temperature for 1 hour. The resulting solid was collected by filtration, washed with water and then dried at 90° C. under a reduced pressure to obtain 269 mg of 5-tert-butyl-2-methyl-1-(2-phenylethyl)-1H-pyrrole-3-carboxylic acid as a colorless solid.