Iodine → 1-Ethylsulfanylsulfonyl-4-methylbenzene

反応式

[CH2:1]([S:3]SCC)[CH3:2].[C:7]1([CH3:16])[CH:12]=[CH:11][C:10]([S:13]([O-:15])=[O:14])=[CH:9][CH:8]=1.[Na+].II>>[C:7]1([CH3:16])[CH:12]=[CH:11][C:10]([S:13](=[O:15])([S:3][CH2:1][CH3:2])=[O:14])=[CH:9][CH:8]=1

参加物

反応物 3

HCID 807Iodine

HCID 8077Diethyl disulfide

HCID 2723791Sodium p-toluenesulfinate

生成物 1

HCID 4800411-Ethylsulfanylsulfonyl-4-methylbenzene収率 100%

実験手順

The reaction was carried out using 0.60 mL (4.87 mmoL) of diethyl disulfide, 2.78 g (15.6 mmoL) of sodium p-toluenesulfinate, 2.47 g (9.74 mmoL) of iodine in accordance with the method of Reference Example 3, and the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1) to obtain 2.11 g of the heading compound as a colorless oily substance (yield 100%).

後処理

customthe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1)

出典と根拠

ORDレコード: ord-e4712a18d0d144cbaaf6ae12dbb30cd8
出典データセット: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08222407B2

反応ノート

読み込み中…