Hydrochloric Acid → 5-Acetoxymethyl-7-nitro-1H-indole-2-carboxylic acid methyl ester

HRID 1515250ノート

反応式

HRID 1515250 の反応式
[CH3:1][O:2][C:3]([C:5]1[N:6](C(OC(C)(C)C)=O)[C:7]2[C:12]([CH:13]=1)=[CH:11][C:10]([CH2:14][O:15][C:16](=[O:18])[CH3:17])=[CH:9][C:8]=2[N+:19]([O-:21])=[O:20])=[O:4].Cl>ClCCl>[CH3:1][O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][C:10]([CH2:14][O:15][C:16](=[O:18])[CH3:17])=[CH:9][C:8]=2[N+:19]([O-:21])=[O:20])=[O:4]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 594480931-BOC-5-acetoxymethyl-7-nitro-indole-2-carboxylic acid methyl ester

生成物 1

HCID 595429365-Acetoxymethyl-7-nitro-1H-indole-2-carboxylic acid methyl ester収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1-BOC-5-acetoxymethyl-7-nitro-indole-2-carboxylic acid methyl ester (4.7 g, 12.0 mmol) prepared in Step A was dissolved in dichloromethane (50 mL). 2N hydrochloric acid solution (30 mL, 60 mmol) was added thereto, and the mixture was stirred for 12 h at room temperature. The reaction mixture was distilled under reduced pressure to give the solid title compound (3.5 g, Yield 100%).

後処理

  1. distillationThe reaction mixture was distilled under reduced pressure

出典と根拠

ORDレコード
ord-a00953e96ec246d489a18383b2fe10fd
出典データセット
uspto-grants-2012_07
特許番号
US08222414B2

反応ノート

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