Acetyl hypofluorite → 2-Acetoxy-4-methylpyridine

反応式

[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.F[O:10][C:11](=O)[CH3:12]>>[C:11]([O:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1)(=[O:10])[CH3:12]

参加物

反応物 2

HCID 127602Acetyl hypofluorite

HCID 178428601HCID 178428601、化合物

生成物 1

HCID 122581882-Acetoxy-4-methylpyridine

実験手順

As a process for the preparation of 2-hydroxy-4-methylpyridine, a process whereby [iv]-4-methylpyridine is reacted with acetyl hypofluorite at −10° C. to obtain a 2-acetoxy-4-methylpyridine, and thereafter the 2-acetoxy-4-methylpyridine is hydrolyzed to obtain 4-methyl-2-pyridone is reported [Journal of the American Chemical Society, 109, 3789-3790, (1987): Non-Patent Reference 2].

出典と根拠

ORDレコード: ord-211211d4fbe349f594fdf97b1263bdff
出典データセット: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08227234B2

反応ノート

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