Chloroacetic Acid → N,N-Diethylglycine

HRID 1516136

反応式

HRID 1516136 の反応式
Cl[CH2:2][C:3]([OH:5])=[O:4].[CH2:6]([NH:8][CH2:9][CH3:10])[CH3:7]>>[CH2:6]([N:8]([CH2:2][C:3]([OH:5])=[O:4])[CH2:9][CH3:10])[CH3:7]

参加物

3

反応物 2

HCID 300Chloroacetic AcidHCID 8021Diethylamine

生成物 1

HCID 74151N,N-Diethylglycine収率 104.8%

実験手順

A solution of chloroacetic acid (30 g, 0.32 mol) in diethylamine (230 mL, 2.2 mol) was stirred overnight. The obtained white precipitate was removed by filtration. The filtrate was evaporated to dryness to afford yellow oil to which EtOAc (300 mL) was added. The obtained precipitate was again removed by filtration. The filtrate was evaporated to afford yellow solid residue (44 g) that was washed with hexane (2×100 mL), EtOAc (2×50 mL) and again with hexane (50 mL), and then dried in vacuo to afford title Intermediate 2 (38 g).

後処理

  1. customThe obtained white precipitate was removed by filtration
  2. customThe filtrate was evaporated to dryness
  3. customto afford yellow oil to which EtOAc (300 mL)
  4. additionwas added
  5. customThe obtained precipitate was again removed by filtration
  6. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-c050af519d4d4415a82bd6b1297327ed
出典データセット
uspto-grants-2012_07
特許番号
US08227428B2

関連ノート

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