Dimethylamine → Methyl 6-dimethylamino-4-(trifluoromethyl)-pyridine-3-carboxylate

HRID 1516391ノート

反応式

HRID 1516391 の反応式
Cl[C:2]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[CH3:16][NH:17][CH3:18]>O>[CH3:16][N:17]([CH3:18])[C:2]1[N:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1

参加物

4

反応物 2

HCID 674DimethylamineHCID 2775340Methyl 6-chloro-4-(trifluoromethyl)nicotinate

生成物 1

HCID 68933112Methyl 6-dimethylamino-4-(trifluoromethyl)-pyridine-3-carboxylate

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 2.5 g (10.43 mmol) of methyl 6-chloro-4-(trifluoromethyl)nicotinate and 18.4 ml (146 mmol) of a 40% solution of dimethylamine in water is heated at 100° C. for 1 hour. A precipitate is subsequently collected by filtering the cooled mixture and is washed with 150 ml of water. After drying under reduced pressure, 2.3 g of the expected compound are isolated.

後処理

  1. customA precipitate is subsequently collected
  2. filtrationby filtering the cooled mixture
  3. washis washed with 150 ml of water
  4. dry with materialAfter drying under reduced pressure, 2.3 g of the expected compound
  5. customare isolated

出典と根拠

ORDレコード
ord-9787a9b6ee454aa89cb9e9406248b7bf
出典データセット
uspto-grants-2012_07
特許番号
US08227489B2

反応ノート

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