Hydrazine Sulfate → 4-Bromopyridazine-3,6-diol
反応式
S(O)(O)(=O)=O.[NH2:6][NH2:7].[Br:8][C:9]1[C:10](O[C:13](=[O:15])[CH:14]=1)=[O:11]>O>[Br:8][C:9]1[C:10](=[O:11])[NH:6][NH:7][C:13](=[O:15])[CH:14]=1参加物
4
実験手順
Hydrazine sulphate salt (51 g) was suspended in water (250 ml), heated to reflux and bromomaleic anhydride (90.38 g) was added dropwise. The mixture was heated at reflux for 4 hours then cooled to room temperature. The reaction was repeated with 29 g hydrazine sulphate, 53 g bromomaleic anhydride and 130 ml water. The precipitates were collected by filtration, washed with water and acetone and dried as a combined batch in vacuo to afford 4-bromo-1,2-dihydro-3,6-pyridazinedione as a white solid (113 g).
後処理
- temperatureheated
- temperatureto reflux
- temperatureThe mixture was heated
- temperatureat reflux for 4 hours
- filtrationThe precipitates were collected by filtration
- washwashed with water and acetone
- customdried as a combined batch in vacuo
出典と根拠
- ORDレコード
- ord-d45f37f166944474839658fa69d9d642
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732460B2
反応ノート
読み込み中…