Hydroxylamine → HCID 86645281、化合物

HRID 1517142ノート

反応式

HRID 1517142 の反応式
[Br:1][C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[CH:7][C:6]=2[C:5]([CH:12]=O)=[CH:4][CH:3]=1.[NH2:14][OH:15]>C(O)C>[Br:1][C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[CH:7][C:6]=2[C:5]([CH:12]=[N:14][OH:15])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 787HydroxylamineHCID 58488145HCID 58488145、化合物

生成物 1

HCID 86645281HCID 86645281、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred solution of 8-bromo-5-isoquinolinecarboxaldehyde (i.e. a product from Step A) (75 mg, 0.3 mmol) in ethanol (7 mL) was added an aqueous solution of hydroxylamine (0.5 mL, 50% in water). After stirring at room temperature overnight, the reaction mixture was concentrated under reduced pressure to provide the title compound as a yellow solid (70 mg).

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-d4ca3ea702c14f549e06d40ac7cefa3c
出典データセット
uspto-grants-2012_07
特許番号
US08231888B2

反応ノート

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