Acetic Acid → HCID 136389259、化合物

HRID 1517394ノート

反応式

HRID 1517394 の反応式
[NH2:1][C:2]1[NH:3][C:4](=[O:22])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.[C:23](O)(=[O:25])[CH3:24]>C(OC(=O)C)(=O)C>[C:23]([NH:1][C:2]1[NH:3][C:4](=[O:22])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1)(=[O:25])[CH3:24]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 1362700182-Amino-6-(3,4-dimethoxyphenyl)pyrido[3,2-d]pyrimidin-4(1H)-one

生成物 1

HCID 136389259HCID 136389259、化合物収率 77%

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

2-amino-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidin-4(3H)-one (2.0 g, 6.70 mmol) was suspended in acetic anhydride (180 ml) and acetic acid (20 ml) and the mixture was refluxed for 16 hours. The hot suspension was filtered and the filtrate was concentrated under reduced pressure until crystallization started. The precipitate was filtered off to give the pure title compound (1.76 g, yield 77%) which was characterized by its mass spectrum as follows: MS (m/z): 341 ([M+H]+, 100).

後処理

  1. filtrationThe hot suspension was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure until crystallization
  3. filtrationThe precipitate was filtered off

出典と根拠

ORDレコード
ord-02c12462fd6440788eed3d0c757f861e
出典データセット
uspto-grants-2012_07
特許番号
US08232278B2

反応ノート

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