Ammonia → 6-(4-Fluorophenyl)pyrido[3,2-d]pyrimidin-4-amine

HRID 1517439ノート

反応式

HRID 1517439 の反応式
[NH3:1].Cl[C:3]1[C:4]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[CH:10]=[CH:9][C:5]=2[N:6]=[CH:7][N:8]=1>CO>[NH2:1][C:3]1[C:4]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[CH:10]=[CH:9][C:5]=2[N:6]=[CH:7][N:8]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 579067564-Chloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine

生成物 1

HCID 576983546-(4-Fluorophenyl)pyrido[3,2-d]pyrimidin-4-amine収率 83%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To an ammonia solution in methanol (5 ml of a 6 M solution) was added 4-chloro-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine (26 mg, 0.1 mmol). The mixture was stirred at room temperature for 12 hours. After concentration under reduced pressure, the residue was purified by silica gel flash chromatography, the mobile phase being a mixture of methanol and dichloromethane, in a volume ratio of 1:30, yielding the title compound (20 mg, yield 83%) as a white solid which was characterised by its mass spectrum as follows: MS (m/z): 241 ([M+H]+, 100).

後処理

  1. concentrationAfter concentration under reduced pressure
  2. customthe residue was purified by silica gel flash chromatography
  3. additiona mixture of methanol and dichloromethane

出典と根拠

ORDレコード
ord-c8c1b32e1e9649d1ae86b1ca3628fc0c
出典データセット
uspto-grants-2012_07
特許番号
US08232278B2

反応ノート

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