Morpholine → 6-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-2-amine

HRID 1517460ノート

反応式

HRID 1517460 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]=[C:7]([NH2:17])[N:8]=[C:9]([N:12]3[CH:16]=NC=N3)[C:10]=2[N:11]=1.N1C[CH2:22][O:21][CH2:20][CH2:19]1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]=[C:7]([NH2:17])[N:8]=[C:9]([N:12]3[CH2:16][CH2:22][O:21][CH2:20][CH2:19]3)[C:10]=2[N:11]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 576983146-Chloro-4-(1H-1,2,4-triazol-1-yl)pyrido[3,2-d]pyrimidin-2-amine

生成物 1

HCID 576983306-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-2-amine収率 244.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A suspension of 6-chloro-4-[1,2,4]triazol-1-yl-pyrido[3,2-d]pyrimidin-2-ylamine (0.1 g, 0.4 mmol) and morpholine (0.07 mL, 0.8 mmol) in DCM (10 mL) was stirred at room temperature for 48 hours. After the removal of solvent, the residue was purified by flash chromatography (using 5% i-PrOH/DCM as the eluent), providing the title compound (0.26 g, 99% yield) as a yellow solid which was characterised as follows: MS (m/z) 266.0 [M+H]+.

後処理

  1. customAfter the removal of solvent
  2. customthe residue was purified by flash chromatography (

出典と根拠

ORDレコード
ord-9192569dccb84dbf97a5d896373e223e
出典データセット
uspto-grants-2012_07
特許番号
US08232278B2

反応ノート

読み込み中…