Bromine → HCID 67374784、化合物

HRID 1517549ノート

反応式

HRID 1517549 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[C:12]([CH3:15])([CH3:14])[CH3:13])[C:6]([OH:8])=[O:7].CC([O-])=O.[Na+].[Br:21]Br>CC(O)=O>[Br:21][C:9]1[C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]([O:2][CH3:1])=[C:11]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH:10]=1

参加物

5

反応物 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 127397584-tert-Butyl-3-methoxybenzoic acid

生成物 1

HCID 67374784HCID 67374784、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
50 °C

実験手順

step 1—To a solution of 3-methoxy-4-tert-butylbenzoic acid (1.0 eq, 48.02 mmol, 10.00 g and NaOAc (2.0 eq, 96.03 mmol, 7.88 g) in HOAc (75 mL) at RT was added dropwise Br2 (2.0 eq, 96.03 mmol, 4.94 mL). The resulting mixture was heated at 50° C. for 24 h, cooled to RT and poured into a mixture of ice-water. The slightly orange-colored solid was collected by suction filtration, washed with water, dried in the oven at 40° C. to afford 12.87 g of 6-bromo-4-tert-butyl-3-methoxybenzoic acid the product (118).

後処理

  1. temperaturecooled to RT
  2. filtrationThe slightly orange-colored solid was collected by suction filtration
  3. washwashed with water
  4. customdried in the oven at 40° C.

出典と根拠

ORDレコード
ord-b87c6be46afa4d1b82056429a0d9c82e
出典データセット
uspto-grants-2012_07
特許番号
US08232271B2

反応ノート

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